While it’s predominately lauded for its hormone support benefits, DIM has been picking up steam for its metabolic benefits too. Average rating 5.0 out of 5.0 based on 2 user(s). Test-tube and animal studies likewise suggest that DIM helps fight prostate cancer. To date, research on the health effects of diindolylmethane is fairly limited. Here's what you need to know about how they work and if … However, in a 6-month study in 551 women with cervical abnormalities, taking 150 mg of DIM per day had no effect on cervical cell changes (3, 13). While the exact mechanism is unknown, indole-3-carbinol is thought to be partly responsible (4, 5, 6). Negative interactions with diuretic medications and liver medications have also been reported, as DIM may speed up how quickly medications are broken down in the liver. Read on to find out about the health benefits of DIM for your whole family. Estrogen Metabolism Benefits of DIM Plus Estrogen metabolism can have a positive effect on acne and other skin issues. In supplement form, DIM is frequently prescribed for survivors of breast, uterine and colorectal cancer. An advantage of supplementation with DIM over consumption of large amounts of raw cruciferous vegetables is avoidance of goitrogenic isothiocyanates. Our articles are evidence-based and contain scientific references, fact-checked by experts. Last medically reviewed on July 22, 2020. As a result, DIM supplements have been gaining popularity as a potential treatment for a variety of hormone-related conditions, including acne, menopause symptoms, prostate issues, and certain forms of cancer. As DIM supplements interact with estrogen levels, they may affect people with hormone-sensitive cancers or who are on hormone therapies. However, human studies are limited (1, 2). Our website services, content, and products are for informational purposes only. Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect. Â© 2020 Organic Information Services Pvt Ltd. All the information on this website is for education purpose only. Another benefit of estrogen metabolism is weight loss. DIM may have anti-cancer effects. For women, an excess of estrogen (commonly known as “estrogen dominance”) can result in unpleasant menstrual symptoms, including heavy periods, shorter cycles, and more severe physiological side effects to the mood and energy levels. Read on to learn more about the benefits of supplementing with DIM, as well as the specific effects of using DIM Plus. DIM Plus is one of several supplements that use DIM as the primary ingredient. And then one day, I read about a supplement I hadn’t tried called DIM—diindolylmethane, if we’re being formal—that supposedly works like a charm for hormonal breakouts. by John Staughton (BASc, BFA) Ginger also helps boost bone health, strengthen the immune system, and increase appetite. In a 12-month study, 21 men with high-grade PIN were given either a placebo or 900 mg of DIM per day. It can also be a helpful tool for those struggling to reduce body fat in specific areas of the body. So, the benefits of taking DIM are so many, that every woman can benefit from it. Low Doses of DIM. These amounts can increase three to four times on an individual basis to derive needed benefits for hormone balance and metabolism. Children, pregnant women, and those who are breastfeeding can consume small amounts of this supplement, but not much more than the daily intake one would get from food, which could be in the range of 25-50 mg. However, it is not a plant estrogen or an estrogen mimic, like soy isoflavones. No matter DIM’s effectiveness, it’s always good to eat more cruciferous veggies. While cruciferous vegetables are the primary food source of DIM, you would need to eat several servings every day to reap this compound’s benefits (1). It is also commonly used as preventative medicine for cancer by non-traditional healers, due to its purported anti-cancer effects. This includes cervical dysplasia and respiratory papillomatosis. In fact, it may help combat prostatic intraepithelial neoplasia (PIN), a condition that’s characterized by prostate cell growth and considered to be a precursor to prostate cancer (14). All rice noodles and rice paper wraps are gluten-free as they are made wholly from rice. DIM helps in weight loss – Most women struggling with seemingly impossible weight loss is due to imbalanced estrogen. In general, DIM’s ability to prevent large increases or decreases in estrogen can help with a number of issues, including acne, menopause symptoms, weight gain and even cancer. Vitamonk Nutri DIM Supplement still provides ample benefits like helping with menopause symptoms and balancing hormone levels like most others on the list. We source information from studies, clinical trial findings, and meta-analyses published in peer-reviewed journals. When NOT to Use DIM. DIM supplements resulted in a significantly improved ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone (8). Benefits of DIM There are a number of positive effects of DIM in the body, but there has been a decided lack of research on this substance or its potential impact on long-term health. Adding DIM supplements to your diet can help to strengthen the reactivity and response time of your immune system, among others, despite the relative dearth of conclusive research on the subject. In human research, doses typically range from 108–900 mg per day — though these studies were only related to treatments for cancer and prostate enlargement (8, 9, 14). Although research on DIM is still quite limited, it’s thought to help balance estrogen levels in your body (1). Share: Hormone Balance DIM Background and Benefits. Diindolylmethane (DIM) is the compound in cruciferous vegetables that makes experts advise people at risk for breast cancer to eat more cabbage and broccoli as a preventive measure. Specifically, DIM may stimulate the production of a less potent, more beneficial form of estrogen known as 2-hydroxyestrone (1). Curcumin can also limit weight gain. This is necessary because it will be hard to consume enough cruciferous vegetables in order to get just 10-30 mg of DIM daily. DIM supplement benefits include relieving hot flashes, night sweats and other symptoms of hormonal imbalance. A DIM supplement could help you shed those pesky pounds! Benefits are a lot, a few proved with research and others are still being studied. The excess can be blotted out gently using a tissue. DIM is derived from cruciferous vegetables like Broccoli. Different DIM products will also have different concentrations and compositions, so always read the label and directions carefully. DrFormulas® DIM Plus Bioperine Supplement is specially formulated to support hormone balance. Diindolylmethane is purported to produce changes in estrogen metabolism, a biological process thought to influence the development of certain hormone-dependent cancers such as breast cancer. © 2005-2020 Healthline Media a Red Ventures Company. We are still learning more about the powerful effects of this plant-based nutrient, but here are a few of the science-backed benefits. As we age, our estrogen decreases, which can cause side…, Chemicals may seem like the best route for acne-prone skin, but it’s not your only option. DIM ameliorates experimental liver fibrosis induced by thioacetamide in mice [ 35 ]. If yes, please share your email to subscribe. Such individuals should steer clear of DIM supplements unless under the supervision of a medical professional. Find out about natural and pharmaceutical…, Estrogen is one of the sex hormones that is responsible for women's reproduction abilities. DIM is a compound your body makes from cruciferous vegetables. You can use baking soda, chalk, or dishwashing liquid to loosen the stain before a wash. How to cut and dry rosemary? DIM Supplement normally comes in capsules, sometimes in combination with other supplements to optimize the desired outcome. The appropriate amount for each individual will depend on a number of factors, including age, weight, prior medical conditions, and current medications. Current human research doesn’t show DIM supplements to be toxic or have serious side effects. Benefits of DIM Supplement. Benefits of calamansi juice include bleaching the skin, detoxifying the body, aiding in weight loss & managing diabetes. People on hormone therapies or with certain hormone-related cancers should avoid these supplements. Fight zits and skin damage with all-natural, organic…. However, it is not a plant estrogen or an estrogen mimic, like soy isoflavones. This supplement has amazing cancer-fighting properties. As mentioned above, the primary natural sources of DIM (diindolylmethane) is cruciferous vegetables, such as: There has been no clear evidence that using DIM supplements is dangerous or has an implicit risk, but certain side effects have been reported when the supplement is not taken in moderation, or in conjunction with other medications. Low estrogen is typically seen in younger women and women approaching menopause. Diindolylmethane Benefits May Help Prevent Cancer. Images are provided by Shutterstock & our contributors. Rash, nausea, vomiting, headache, arthralgia and hot flashes have been reported. Estrogen dominance can have a negative effect on both mental and physical health of women, so using DIM to control estrogen levels and mitigate PMS symptoms is a very common practice, although there is a lack of concrete evidence supporting this correlation. In the few clinical studies that have been conducted, it has been suggested that DIM may help prevent the growth of cancer cells — specifically breast cancer cells. DIM stimulates more efficient metabolism for estrogen, meaning it helps regulate the ratio of healthy to less healthy estrogen. Test-tube and animal studies suggest that DIM supplements may help prevent the growth and spread of breast cancer cells. Now a newâ¦, COVID-19 shows a wide range of manifestations among those affected. Other amazing properties of Diindolylmethane include the fact that you can use it as an anti-inflammatory, antiproliferative, antiviral, anti-angiogenesis, antiandrogenic, antibacterial and even for hormone-balancing! All the same, human studies are needed (10, 11, 12). A DIM supplement is a nutritional supplement composed of a phytochemical that our body naturally produces by breaking down a compound in our diet. Taking DIM, together with low-calorie calorie diet & exercise can make weight loss easier. Hormonal acne occurs when there is an unbalance of estrogen levels and an increase in the male hormone, testosterone. There are a number of positive effects of DIM in the body, but there has been a decided lack of research on this substance or its potential impact on long-term health. DIM, short for diindolylmethane, is a hormone balancer. It may also help reduce the effects of a stronger form called 16 alpha-hydroxyestrone, which has been linked to weight gain and an increased risk of some cancers, including breast and uterine cancer (1, 7). Some of the benefits being researched include a positive impact on cancerous cell growth, reduction in acne, prevention of an enlarged prostate, and treatment of the premenstrual syndrome. Some websites say DIM can even help with sexual function in both men and women. There are a number of positive effects of DIM in the body, but there has been a decided lack of research on this substance or its potential impact on long-term health. Other uses of DIM supplements, such as weight loss and acne treatment, have not been studied in humans. Although research is ongoing, increasing the ratio of 2-hydrozyestrone to 16-hydrozyesterone may reduce breast cancer risk and cause anti-tumor effects (8). Diindolylmethane, more commonly abbreviated to DIM, is a beneficial supplement that can help our body regulate itself more efficiently. Estrogen dominance can play a role in the development of acne because it can lead to oily skin and clogged pores. This article provides a comprehensive overview of DIM supplements, including their benefits and side effects. DIM supplements may safeguard against prostate enlargement and prostate cancer. An average diet will likely contain less than 25 mg of diindolylmethane per day, yet some supplements may offer more than 500mg in a daily dose. Still, you may wonder whether these uses are backed by scientific evidence. Diindolylmethane (DIM) is a natural substance found in vegetables like broccoli, cabbage, and cauliflower. Diindolylmethane is used for preventing breast, uterine, and colorectal cancer. DIM has been shown to provide potential protection against hormone-dependent cancers such as breast, uterus and cervical cancer. Still, more human research is necessary (15). DIM supplements is commonly taken in doses of 100 mg to 200 mg. As it affects estrogen levels, DIM may help treat a variety of conditions, including hormone-sensitive cancers and prostate issues. Keep in mind that human studies are needed. However, their effectiveness for other hormone-related conditions hasn’t been widely studied. Intriguingly, observational studies associate high cruciferous vegetable intake with a reduced risk of certain cancers, including breast and prostate cancer. Diindolylmethane supplements—DIM for short—have been credited with combatting breakouts and other period problems. Cruciferous vegetables are low-calorie, and rich in folate, vitamins C, E, and K, and fiber. Dates are sweet fruitsÂ of the date palm tree. It also prevents prostate cancer and BPH. One study analyzes the effect of DIM on 130 women with breast cancer over 12 months. Additionally, DIM has been shown to inhibit an enzyme called aromatase, which converts testosterone to estrogen (1). The study divided the women into two groups; the first group was to take a 150g DIM supplement twice daily, and the second group was to take a placebo. DIM stimulates more efficient metabolism for estrogen, meaning it helps regulate the ratio of healthy to less healthy estrogen. A study carried out by theâ¦. Test-tube and animal studies indicate that DIM protects against ovarian, prostate, and colon cancers as well. A way to remedy excess estrogen is to try…, Men trying to manage their testosterone levels may turn to estrogen blockers to help balance their hormones. Many of the published studies on the benefits of DIM have used BioResponse DIM because generic DIM (ie. Traditionally used as an add-on to prevent the recurrence of a rare respiratory disease, this compound is now being investigated as a cancer-preventing agent. Take DIM with Milk Thistle for Liver detox & Endometriosis: Taking DIM with another supplement called milk thistle has been shown to reduce the severity of endometriosis. In preliminary research, some scientists have found that diindolylmeth… If you take a DIM supplement, you’re bypassing these steps but can still take full advantage of the health benefits of DIM. The scientific community continues to reveal the numerous benefits of this supplement and the findings so far are positive and promising. DIM supplements contain diindolymethane, which is found in cruciferous vegetables like broccoli and cabbage. Before taking these supplements, get dosage guidance from your healthcare provider. DIM supplements are being studied for their protective effects against certain cancers. It will likewise urge estrogen to separate into the ‘great’ metabolites as opposed to the ‘terrible’ ones. DIM can mitigate the level of estrogen in the body by stimulating the breakdown of estrogen in beneficial metabolites. Proponents claim that consuming diindolylmethane can help increase your defense against several types of cancer, as well as promote detoxification and support weight loss. DIM Supplement Benefits DIM is most effective in helping maintain hormonal balance, especially between estrogen and testosterone in both men and women. DIM and Hormonal Acne. You can continue to get DIM through eating cruciferous vegetables and letting your body do the natural process to produce DIM; but be careful how you cook these vegetables. It is naturally obtained via dietary consumption of cruciferous vegetables. Diindolylmethane, or DIM, is a natural chemical formed in your digestive tract from a compound called glucobrassicin, which is contained in cruciferous vegetables such as broccoli, cauliflower and cabbage. Our DIM hormone therapy supplement is derived from broccoli and pomegranate. Kid Influencers Promoting Junk Food On YouTube, Study Finds, Study Shows How Musical Training Improves Cognitive Function, Study Reveals Why Some People Show Severe COVID Symptoms, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059820/, https://www.worldscientific.com/doi/abs/10.1142/9789814719094_0005, https://academic.oup.com/mend/article/23/12/1940/2684044, https://www.researchgate.net/profile/Jianbin_Zheng/publication/8572652_Anticarcinogenic_and_antioxidant_activity_of_diindolylmethane_derivatives/links/55c371a308aea2d9bdc17302/Anticarcinogenic-and-antioxidant-activity-of-diindolylmethane-derivatives.pdf, https://www.antiaging-systems.com/articles/209-estrogen-the-unrecognized-male-hormone, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759426/, https://books.google.com/books?id=geSVDgAAQBAJ, 12 Proven Health Benefits of Apple Cider Vinegar, Hibiscus Tea: Benefits, How to Make, & Side Effects, Calamansi Juice: Benefits, Recipe, and Side Effects. 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